How to fold a linear chromosome of Streptomyces

 How to fold a linear chromosome of Streptomyces
Fig. 1: Spatial organisation of the S. venezuelae linear chromosome during sporulation. A The S. venezuelae (wild-type ftsZ-ypet derivative, MD100) growth curve (in 5 ml culture), performed in n = 3 independent experiments. The mean optical density values and standard deviation (whiskers) are shown on the scheme. The critical time points of sporogenic development are marked with arrows: growth arrest and cessation of DNA replication (red), the appearance of FtsZ ladders (green) and the spore formation (blue). The normalised FtsZ-YPet fluorescence (a marker of a synchronous cell division) [U/µg] and the relative oriC/arm ratio (a marker of DNA replication; n = 3 independent experiments: mean oriC/arm values as well as calculated standard deviations (whiskers) are shown on the diagram) are shown as insets in the plot, with X axes corresponding to the…

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